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If your doctor thinks your lymphoma is more likely to behave like Burkitt lymphoma or classical Hodgkin lymphoma , instead, they might suggest the treatments commonly used for these types of lymphoma.

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You might be offered an intensive treatment if your lymphoma has features that suggest it may be difficult to treat. Double-hit and triple-hit lymphoma can be difficult to treat and have higher relapse rates the lymphoma coming back than more common types of DLBCL.

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If you are fit enough, your doctor might suggest intensive chemo-immunotherapy chemotherapy with antibody therapy. Some people might be offered a stem cell transplant after successful treatment.


Stem cell transplants may reduce the risk of relapse. Some people might be offered treatment as part of a clinical trial. Some clinical trials aim to find out which existing treatment regimen combination of drugs works best for these rare lymphomas. Other clinical trials test newer drugs and new combinations of treatments to find out if they are effective.

Find out more about clinical trials and search for a trial that might be suitable for you at Lymphoma TrialsLink. It can be difficult to find relevant information if your lymphoma does not fit into any of the more usual types. You might find it helpful to read information on the type of lymphoma it most closely resembles.

Grey zone, double-hit, triple-hit, and high-grade B-cell lymphomas, not otherwise specified (NOS)

Ask your doctor for advice on what information is most relevant for you. They can advise you based on your individual circumstances.

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Read Kat's story Back to top. If you would like further information or would like to talk about any aspect of your lymphoma, please contact us. Back to top Double-hit and triple-hit lymphoma A high-grade B-cell lymphoma with more than one major lymphoma-related genetic change in the lymphoma cells might be called: Back to top Treatment There is no standard treatment for grey zone lymphoma, double-hit or triple-hit lymphoma or high-grade B-cell lymphoma, NOS.

Back to top Finding information It can be difficult to find relevant information if your lymphoma does not fit into any of the more usual types. Diffuse large B-cell lymphoma. However, it is important to document this entity as it has distinct prognostic and therapeutic implications. Currently, the challenge is how to adequately screen for this entity. Most users should sign in with their email address.

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About the BMX Triple Hit Event

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